制药计量Coated Pharmaceutical Dosage Forms 下载 网盘 kindle mobi 115盘 pdf pdb rtf

This book is an updated English edition of the German version Uberzogene Arzneiformen. It has now been revised and completed to cover the recent developments in coating technology of the last ten years.

It is a basic guideline and a reference book for everyday problems, which includes.

Sugar and film coating; procedures and materials biopharmaceutical aspects and controlled release; production equipment and processes; test methods and stability.

The authors are professionals from industry and university, who wish to pass on their experience to pharmacists in drug development or production and to other persons responsible in industrial candy production.

Preace

Contents

List of Abbreviations

Explanation of Terms

1 Introduction

1.1 History of Coated Pharmaceutical Dosage Forms

1.2 Focal Poins and Trends in Modern Coating Technology

1.3 Purpose of Coating

1.4 Types

1.5 Active Ingredients in Coatings

1.6 Microbial

2 The Core or Srbstrate

2.1 Types,Shapes and Characteristics of Cores

2.2 Calculation of Amount of Coating Material for Various Types of Cores

3 Sugar-Coated and Other Non-Film Coating Products

3.1 Sugar-Coated and Other Non-Film Coating Processes

3.2 Manufacture of Coatings

3.3 Problems

4 Film Coating

4.1 Interactions Between Sub-strate and Film

4.2 Coating Processes

4.3 Developing the Formulation

4.4 Problems

5 Biopharmaceutical Aspects

5.1 Objectives of Controlled Drug Releasd and Controlled Drug Release and Control Principles

5.2 Environmental Conditions in the Digestive Tract and their Imfluence on the Dosage From

5.3 Variations in the Environmental Conditions of the Digestive Tract

5.4 Biopharmaceutical Problems and Limits of the Effectiveness of Coatings on Pharmaceutical Dosage Forms

5.5 Practical Consequences and Examples

6 Coloring and Flavoring of Coated Dosage Forms

6.1 Coloring

6.2 Flavoring

7 Equipment for sugar Coating and Film Coating Pocesses

7.1 Process Parameters

7.2 Conventional Coating Pans and Belt Coaters

7.3 Conventional Coating Pans with Improved Drying Efficiency

7.4 Perforated Pans Rotating on Horizontal Axes

7.5 Fluidized-Bed or Air-Suspen-sion Coaters

7.6 Vacuum Coater with Solvent Recovery and Energy

7.7 Selection Criteria for Coating Equipment

7.8 Peripheral Equipment

8 Testing of Coated Dosage Forms

8.1 Testing of Coating Materials

8.2 Testing of Coated Dosage Forms

9 Stability Problems

9.1 Stability of Sugars and Sugar Solutions

9.2 Stability of Sugar-Coated Products

9.3 Stability of the Film Formers

9.4 Incompatibilities and Stability Problems of Coating Formulations

9.5 Stability of Film-Coated Tablets

10 Raw Materials

10.1 Sugars and Sugar Alcohols

10.2 Film Formers

10.3 Plasticizers

10.4 Colorants

10.5 Other Raw Materials

Index

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